Molecular human cytogenetics
نویسندگان
چکیده
منابع مشابه
Human Cytogenetics: from Classical to Molecular Karyotyping
The establishment of human diploid chromosome number (Tjio and Levan, 1956), have led to the foundations of human cytogenetics. Since then, due to the rapid developments of new techniques for chromosome analysis, many other chromosome disorders were recognized. The introduction of banding techniques, yielding a highly reproducible banding pattern, allowed the reliable identification of every si...
متن کاملHuman molecular cytogenetics: From cells to nucleotides
The field of cytogenetics has focused on studying the number, structure, function and origin of chromosomal abnormalities and the evolution of chromosomes. The development of fluorescent molecules that either directly or via an intermediate molecule bind to DNA has led to the development of fluorescent in situ hybridization (FISH), a technology linking cytogenetics to molecular genetics. This t...
متن کاملPractical Human Cytogenetics
ALTHOUGH attempts at establishing the human chromosome number dates from early in this century, it was not until 1957 when improvements in techniques became available that human cytogenetics became established as a laboratory discipline. Since 1959, many clinical disorders ranging from abnormalities of sexual, physical and intellectual development, pregnancy wastage, leukaemia and tumours, have...
متن کاملProgress in the molecular cytogenetics of man.
Recombinant DNA technology has contributed greatly to the precision of chromosome analysis in man. Breakpoints of chromosome deletions and rearrangements may be defined on a chromosome map whose landmarks are the loci of DNA sequences rather than Giemsa bands. Flow cytogenetics allows the extent of chromosome duplications and deletions to be measured more precisely than has hitherto been possib...
متن کاملComparative Molecular Cytogenetics and Chromosome Evolution
ABC Fax + 41 61 306 12 34 E-mail [email protected] www.karger.com © 2005 S. Karger AG, Basel 0301–0171/05/1083–0139$22.00/0 Accessible online at: www.karger.com/cgr Abstract. For the last 15 years molecular cytogenetic techniques have been extensively used to study primate evolution. Molecular probes were helpful to distinguish mammalian chromosomes and chromosome segments on the basis of their ...
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ژورنال
عنوان ژورنال: Nature
سال: 1977
ISSN: 0028-0836,1476-4687
DOI: 10.1038/266589a0